Edmonton protocol

The Edmonton Protocol is a method of implantation of pancreatic islets for the treatment of type 1 diabetes mellitus, specifically "brittle" type 1 diabetics prone to hypoglycemic unawareness. The protocol is named for the islet transplantation group at the University of Alberta in the Canadian city of Edmonton, where the protocol was first devised in the late 1990s, and published in The New England Journal of Medicine in July 2000.

Procedure

The Edmonton Protocol involves isolating islets from a cadaveric donor pancreas using a mixture of enzymes called Liberase (Roche). Each recipient receives islets from one to as many as three donors. The islets are infused into the patient's portal vein, and are then kept from being destroyed by the recipient's immune system through the use of two immunosuppressants, sirolimus and tacrolimus as well as a monoclonal antibody drug used in transplant patients called daclizumab.

History

Islet isolation and transplantation was pioneered by Paul Lacy throughout the 1960s. He and Walter Ballinger together were able to restore normoglycaemia in diabetic rats following the transplantation of isolated islets into the rodent's livers. Scientists have not yet successfully translated Dr. Lacy's success in rodents to humans.

Edmonton

Edmonton ⁱ/ˈɛdməntən/ is the capital of the Canadian province of Alberta. Edmonton is on the North Saskatchewan River and is the centre of the Edmonton Capital Region, which is surrounded by Alberta's central region.

The city had a population of 877,926 in the 2014 census, making it Alberta's second-largest city and Canada's fifth-largest municipality. This population represents 66 percent of the total 2014 population of 1,328,300 within the Edmonton census metropolitan area (CMA), Canada's fifth-largest CMA by population. Edmonton is the northernmost North American city with a metropolitan population over one million. A resident of Edmonton is known as an Edmontonian.

Edmonton's historic growth has been facilitated through the absorption of five adjacent urban municipalities (Strathcona, North Edmonton, West Edmonton, Beverly and Jasper Place) and a series of annexations ending in 1982. Edmonton serves as the northern anchor of the Calgary–Edmonton Corridor. Known as the "Gateway to the North", the city is a staging point for large-scale oil sands projects occurring in northern Alberta and large-scale diamond mining operations in the Northwest Territories.

Edmonton (disambiguation)

Edmonton is the capital city of the Canadian province Alberta. It may also refer to:

Cities and towns

Electoral districts

Edmonton (Via Rail station)

Edmonton railway station is on the Canadian National Railway mainline in Edmonton, Alberta. The railway station is located near the Edmonton City Centre Airport, approximately 5.5 kilometres from the city centre. Served by Via Rail's The Canadian three times per week in each direction, the station is unusually located on a branch of the main line, meaning that trains must either reverse into or out. The station opened in 1998 following the closure of the downtown Via Rail station which was located in the lower level of Edmonton's CN Tower.

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